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tecovirimat will enhance the degree or result of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Use Caution/Keep track of. Tecovirimat is a weak inhibitor of CYP2C8 and CYP2C19. Watch for adverse effects if coadministered with delicate substrates of such enzymes.Suicidal Conduct and Ideation: Antiepileptic medications (AEDs), including